Odagiri Takato
Laboratory of Influenza Viruses, Department of Virology 3, National Institute of Infectious Diseases.
Nihon Rinsho. 2006 Oct;64(10):1855-64.
Outbreaks caused by highly pathogenic H5N1 avian influenza viruses have spread worldwide and the containment is impossible no longer. During the outbreaks, over 200 human infection cases with 55% fatality are confirmed at the moment and some human-to -human transmission in family clusters have been observed in Vietnam, Thailand and Indonesia. The potency of pandemic caused by highly pathogenic H5N1 avian influenza is increasing gradually. Consequently, development of effective H5N1 vaccine and its licensing for vaccination to human are urgent countermeasures for pandemic preparedness. In the present article, the author reviews the development of H5N1 attenuated vaccine by reverse genetic technology and discuss the problems on the vaccine production to be dissolved before pandemic occur.
高致病性H5N1禽流感病毒引发的疫情已在全球蔓延，遏制疫情已不再可能。在疫情爆发期间，目前已确诊200多例人类感染病例，死亡率达55%，并且在越南、泰国和印度尼西亚已观察到在家庭群组中出现了一些人传人现象。高致病性H5N1禽流感引发大流行的可能性正在逐渐增加。因此，开发有效的H5N1疫苗并将其许可用于人类接种是防范大流行的紧迫对策。在本文中，作者回顾了利用反向遗传学技术开发H5N1减毒活疫苗的情况，并讨论了在大流行发生之前疫苗生产中有待解决的问题。
