Safaralizadeh R, Siavoshi F, Malekzadeh R, Akbari M R, Derakhshan M H, Sohrabi M R, Massarrat S
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
East Mediterr Health J. 2006 May-Jul;12(3-4):286-93.
The occurrence of strains resistant to metronidazole is causing failure of the 4-drug regimen for eradication of Helicobacter pylori in the Islamic Republic of Iran. This study compared the in vitro efficacy of furazolidone with metronidazole, clarithromycin, amoxicillin and tetracycline in 70 H. pylori isolates from dyspeptic patients. Of the isolates, 33% were resistant to metronidazole but all were susceptible to furazolidone. Furazolidone could be considered as an appropriate substitute for metronidazole for H. pylori infections.
耐甲硝唑菌株的出现导致伊朗伊斯兰共和国用于根除幽门螺杆菌的四联疗法失效。本研究比较了呋喃唑酮与甲硝唑、克拉霉素、阿莫西林和四环素对70株来自消化不良患者的幽门螺杆菌分离株的体外疗效。在这些分离株中，33%对甲硝唑耐药，但对呋喃唑酮均敏感。呋喃唑酮可被视为幽门螺杆菌感染时甲硝唑的合适替代药物。
