Andersson Jenny, Johannessen Espen, Areva Sami, Järn Mikael, Lindén Mika
Department of Physical Chemistry, Abo Akademi University, Porthansgatan 3-5, FIN-20500 Turku, Finland.
J Nanosci Nanotechnol. 2006 Aug;6(8):2438-44. doi: 10.1166/jnn.2006.515.
This paper describes a method by which a porous silica coating layer can be obtained on different apatite particles through a simple sol-gel synthesis route. Sol-gel derived powders of hydroxyapatite (HAP) and beta tricalciumphosphate (beta-TCP) were coated with a mesoporous silica using C16TAB (hexadecyltrimethylammonium bromide) as a template in order to induce mesophase formation. Further calcination of the material removes the template from the mesophase and leaves a highly ordered hexagonal arranged mesoporous silica structure with a core of HAP/beta-TCP. The phase purity of the SiO2/apatite composites has been thoroughly investigated by the means of FT-IR, XRD, and solid state 31P MAS NMR. The phase purity of these materials is shown to be dependent on the solubility properties of the used apatites. The hybrid materials are suitable as a multifunctional biomaterial where osteoconductive properties can be combined with drug delivery.
本文描述了一种方法，通过该方法可以通过简单的溶胶-凝胶合成路线在不同的磷灰石颗粒上获得多孔二氧化硅涂层。以十六烷基三甲基溴化铵（C16TAB）为模板，对溶胶-凝胶法制备的羟基磷灰石（HAP）和β-磷酸三钙（β-TCP）粉末进行介孔二氧化硅涂层处理，以诱导中间相形成。对该材料进一步煅烧可从中间相中去除模板，留下具有HAP/β-TCP核心的高度有序的六方排列介孔二氧化硅结构。通过傅里叶变换红外光谱（FT-IR）、X射线衍射（XRD）和固态31P魔角旋转核磁共振（31P MAS NMR）手段对SiO2/磷灰石复合材料的相纯度进行了深入研究。结果表明，这些材料的相纯度取决于所用磷灰石的溶解性。这种杂化材料适合作为一种多功能生物材料，可将骨传导性能与药物递送相结合。
