[麻疹病毒的细胞嗜性与适应性]

[Cellular tropism and adaptation of the measles virus].

作者信息

Ohno Shinji, Yanagi Yusuke

机构信息

Department of Virology, Faculty of Medicine, Kyushu University, Japan.

出版信息

Uirusu. 2006 Jun;56(1):27-34. doi: 10.2222/jsv.56.27.

DOI:10.2222/jsv.56.27

PMID:17038809

Abstract

Measles virus (MV) is a member of the genus Morbillivirus in the family Paramyxoviridae. Clinical isolates of MV use signaling lymphocyte activating molecule (SLAM) as a cellular receptor. SLAM is mainly expressed on immune cells such as immature thymocytes, activated lymphocytes and mature dendritic cells. This distribution of SLAM can account for the lymphotropism of MV. On the other hand, laboratory strains of MV use CD46 as an alternative receptor, through amino acid change(s) in the receptor binding hemagglutinin protein. Recently, several reports imply the existence of the cellular receptor(s) other than SLAM and CD46. In this review, we discuss the receptor usage of MV and its adaptation to cultured cells.

摘要

麻疹病毒（MV）是副粘病毒科麻疹病毒属的成员。MV的临床分离株使用信号淋巴细胞激活分子（SLAM）作为细胞受体。SLAM主要在未成熟胸腺细胞、活化淋巴细胞和成熟树突状细胞等免疫细胞上表达。SLAM的这种分布可以解释MV的嗜淋巴细胞性。另一方面，MV的实验室毒株通过受体结合血凝素蛋白中的氨基酸变化，使用CD46作为替代受体。最近，一些报告暗示存在除SLAM和CD46之外的细胞受体。在这篇综述中，我们讨论了MV的受体使用情况及其对培养细胞的适应性。