Lagorce J F, Jambut-Absil A C, Buxeraud J, Moesch C, Raby C
Laboratory of Chemical Pharmacy, Faculty of Pharmacy, Limoges University, France.
Chem Pharm Bull (Tokyo). 1990 Aug;38(8):2172-4. doi: 10.1248/cpb.38.2172.
It has been demonstrated spectroscopically that many nitrogen-containing heterocyclic compounds can form charge transfer complexes with iodine. The complexes of morpholine with iodine were shown to be of the n-sigma type with a 1:1 stoichiometry. A strong donor-acceptor interaction was found (Kc = 1261 +/- 12 mol-1 at 20 degrees C in CCl4), considerably higher than those of complexes of aromatic compounds with iodine. The high value of the formation constant for this complex indicated that morpholine could serve as a starting point for the synthesis of novel anti-thyroid drugs.
