Roberts D B, Jowett T, Hughes J, Smith D F, Glover D M
Biochemistry Department, University of Oxford, England.
Eur J Biochem. 1991 Jan 1;195(1):195-201. doi: 10.1111/j.1432-1033.1991.tb15695.x.
Null alleles of all three genes (alpha, beta and gamma) coding for the major serum protein of Drosophila larvae, larval serum protein 1, have been characterized at the protein level and by analysis of their RNA and DNA. Each allele completely lacks one polypeptide chain. beta shows an unaltered gene but reduced levels of RNA, alpha shows restriction-fragment-length polymorphism and shows low levels of transcript, while gamma is a deletion. The three null alleles have been combined to give a strain without the gene for larval serum protein 1 which survives.
编码果蝇幼虫主要血清蛋白——幼虫血清蛋白1的所有三个基因（α、β和γ）的无效等位基因，已在蛋白质水平以及通过对其RNA和DNA的分析进行了表征。每个等位基因完全缺失一条多肽链。β显示基因未改变但RNA水平降低，α显示限制性片段长度多态性且转录本水平较低，而γ是一个缺失突变。这三个无效等位基因已被组合在一起，得到了一个没有幼虫血清蛋白1基因但仍能存活的品系。
