Bakan Mefkur, Kaya Guner, Cakmakkaya Serpil, Tufanogullari Burcu
Cerrahpasa Medical Faculty, Department of Anesthesiology and Reanimation, Istanbul University, Istanbul, Turkey.
Paediatr Anaesth. 2006 Nov;16(11):1184-8. doi: 10.1111/j.1460-9592.2006.01979.x.
A 12-year-old boy with bilateral adrenal pheochromocytoma pretreated with furosemide, nifedipine, prazosin, and propranolol underwent surgical removal of the tumors. General anesthesia with desflurane, remifentanil infusion and thoracic epidural analgesia was performed. To control the blood pressure (BP), remifentanil up to 1 microg.kg(-1).min(-1) infusion rate, sodium nitroprusside, and esmolol infusions were administered successfully. Following the ligation of the adrenal veins, hemodynamic parameters were stable and neither inotropic support nor corticosteroid replacement was required. We concluded that remifentanil-based anesthesia combined with low-dose desflurane and thoracic epidural analgesia may reduce the need for vasoactive drugs in the anesthesia management of pheochromocytoma. This combination may not prevent the hemodynamic fluctuations during tumor manipulation, but appears to facilitate a rapid and stable postoperative recovery.
一名12岁患有双侧肾上腺嗜铬细胞瘤的男孩,术前接受了呋塞米、硝苯地平、哌唑嗪和普萘洛尔治疗,随后接受了肿瘤切除术。采用地氟醚、瑞芬太尼输注和胸段硬膜外镇痛进行全身麻醉。为控制血压(BP),成功给予了高达1微克·千克⁻¹·分钟⁻¹输注速率的瑞芬太尼、硝普钠和艾司洛尔输注。肾上腺静脉结扎后,血流动力学参数稳定,无需使用正性肌力药物支持或皮质类固醇替代治疗。我们得出结论,基于瑞芬太尼的麻醉联合低剂量地氟醚和胸段硬膜外镇痛,可能会减少嗜铬细胞瘤麻醉管理中血管活性药物的使用需求。这种联合用药可能无法预防肿瘤操作期间的血流动力学波动,但似乎有助于术后快速且稳定地恢复。