Kimball Kristopher J, Numnum T Michael, Rocconi Rodney P, Alvarez Ronald D
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Curr Oncol Rep. 2006 Nov;8(6):441-7. doi: 10.1007/s11912-006-0073-x.
Ovarian cancer remains the leading cause of death due to gynecologic cancer in women in the United States. Gene and viral-based therapies represent novel therapeutic approaches for cancer. The manipulation of genetic content of tumor cells toward a therapeutic end has been divided into several general strategies, including molecular chemotherapy, mutation compensation, immunopotentiation, and virotherapy. Improvements in delivery vehicles and in evaluation of gene transfer and viral replication remain important areas of investigation. We highlight the most recent advances in these novel therapeutic approaches for ovarian cancer and include a summary of recent clinical trials.
在美国，卵巢癌仍然是导致女性妇科癌症死亡的主要原因。基于基因和病毒的疗法是癌症的新型治疗方法。将肿瘤细胞的遗传物质用于治疗目的的操作已分为几种一般策略，包括分子化疗、突变补偿、免疫增强和病毒疗法。递送载体以及基因转移和病毒复制评估方面的改进仍然是重要的研究领域。我们重点介绍了这些卵巢癌新型治疗方法的最新进展，并总结了近期的临床试验情况。
