Koella J C
Department of Zoology, University of Aarhus, Universitetsparken B135, DK-8000 Aarhus, Denmark.
Parasitol Today. 1998 Sep;14(9):360-4. doi: 10.1016/s0169-4758(98)01297-6.
Recent experiments have suggested that resistance to antimalarial drugs, in particular chloroquine, is associated with increased transmission. However, epidemiological patterns suggest the opposite: ie. that resistance should be associated with a transmission cost. Here, Jacob Koella reviews the evidence for either a cost or a benefit of chloroquine resistance and proposes ideas from population and evolutionary biology that might explain the apparent contradiction between experimental and epidemiological evidence.
近期的实验表明，对抗疟药物尤其是氯喹的耐药性与传播增加有关。然而，流行病学模式却显示出相反的情况：即耐药性应与传播成本相关。在此，雅各布·凯拉回顾了关于氯喹耐药性的成本或益处的证据，并提出了群体生物学和进化生物学的观点，这些观点或许可以解释实验证据与流行病学证据之间明显的矛盾。
