B族链球菌菌毛蛋白有助于黏附并侵入脑微血管内皮细胞。
Group B streptococcal pilus proteins contribute to adherence to and invasion of brain microvascular endothelial cells.
作者信息
Maisey Heather C, Hensler Mary, Nizet Victor, Doran Kelly S
机构信息
Department of Pediatrics, Division of Pharmacology & Drug Discovery, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA.
出版信息
J Bacteriol. 2007 Feb;189(4):1464-7. doi: 10.1128/JB.01153-06. Epub 2006 Oct 13.
Abstract
Surface filamentous structures known as pili have been discovered recently in the gram-positive streptococcal pathogens that cause invasive disease in humans, including group B Streptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded by pilA and pilB, also facilitate the interaction of this important agent of central nervous system infection with endothelial cells of the human blood-brain barrier.
摘要
最近在引起人类侵袭性疾病的革兰氏阳性链球菌病原体中发现了称为菌毛的表面丝状结构，包括B族链球菌（GBS）。我们发现，由pilA和pilB编码的两种参与菌毛形成的GBS蛋白，也促进了这种中枢神经系统感染的重要病原体与人类血脑屏障内皮细胞的相互作用。
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