Castel M N, Boireau A, Laduron P M
Rhône-Poulenc Santé, Centre de Recherches de Vitry-Alforville, Vitry-sur-Seine, France.
Eur J Pharmacol. 1990 Sep 4;186(1):133-6. doi: 10.1016/0014-2999(90)94070-e.
gamma-Butyrolactone is a drug known to inhibit the flow of electrical impulses in dopaminergic neurones and to prevent dopamine release in the striatum. In this study, we investigated the effects of this compound on the retrograde transport of neurotensin in the nigrostriatal dopaminergic pathway. The amount of radioactivity measured in the substantia nigra after injection of iodinated neurotensin into the striatum and the time course of its accumulation were not found to be modified in gamma-butyrolactone-treated rats. We therefore conclude that the retrograde axonal transport of neurotensin in the nigrostriatal pathway is not affected by reduced dopaminergic firing or by inhibition of the striatal release of dopamine.
γ-丁内酯是一种已知能抑制多巴胺能神经元电冲动传导并阻止纹状体中多巴胺释放的药物。在本研究中，我们研究了该化合物对黑质纹状体多巴胺能通路中神经降压素逆行转运的影响。向纹状体注射碘化神经降压素后，在黑质中测得的放射性量及其积累的时间进程在γ-丁内酯处理的大鼠中未发现有改变。因此，我们得出结论，神经降压素在黑质纹状体通路中的逆行轴突运输不受多巴胺能放电减少或纹状体多巴胺释放抑制的影响。
