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Isolation and characterization of protective cytolytic T cells in a rodent malaria model system.

作者信息

Romero P, Maryanski J L, Cordey A S, Corradin G, Nussenzweig R S, Zavala F

机构信息

Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.

出版信息

Immunol Lett. 1990 Aug;25(1-3):27-31. doi: 10.1016/0165-2478(90)90086-6.

DOI:10.1016/0165-2478(90)90086-6
PMID:1704348
Abstract

Protective immunity against malaria is induced by immunization with irradiation-attenuated sporozoites. Here we report the isolation of cytolytic T-cell (CTL) clones from BALB/c (H-2d) mice immunized with either Plasmodium berghei or Plasmodium yoelii sporozoites. The epitopes recognized by these CTL can be mimicked by synthetic peptides corresponding to a homologous region in the CS proteins of both rodent malaria species. Both peptides are recognized by the CTL in the context of the same MHC class I molecule, H-2 Kd. In vivo adoptive transfer of the CTL clones into non-immune syngeneic mice protected them from a lethal challenge of infectious sporozoites.

摘要

相似文献

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