新一代组织密封剂和止血剂：创新性泌尿外科应用。
New generation tissue sealants and hemostatic agents: innovative urologic applications.
作者信息
Traver Michael A, Assimos Dean G
出版信息
Rev Urol. 2006 Summer;8(3):104-11.
Abstract
Control of blood loss during urologic surgery is paramount to the success of patient recovery. Hemostatic agents and tissue sealants are used routinely to prevent excess blood loss and in reconstruction during surgical repair. Some of the available products include thrombin sealant, fibrin glue, bovine serum/albumin/glutaraldehyde, and gelatin matrix. Each of these agents differs in mechanism, cost, and application. Complications can include allergic reactions or thromboembolism and the risk of contracting bovine spongiform encephalitis or hepatitis. Many new hemostatic agents are being developed and approved. The benefits and risks of use of these agents versus conventional treatment need to be considered on a case-by-case basis by the surgeon.
摘要
泌尿外科手术中控制失血对患者恢复的成功至关重要。止血剂和组织密封剂通常用于防止手术修复过程中过度失血和重建。一些可用产品包括凝血酶密封剂、纤维蛋白胶、牛血清/白蛋白/戊二醛和明胶基质。这些药剂中的每一种在作用机制、成本和应用方面都有所不同。并发症可能包括过敏反应或血栓栓塞以及感染牛海绵状脑病或肝炎的风险。许多新型止血剂正在研发并获批。外科医生需要根据具体情况考虑使用这些药剂与传统治疗相比的益处和风险。
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