49例肛管腺癌患者的临床特征与治疗

[Clinical features and treatment of 49 patients with anal canal adenocarcinoma].

作者信息

Li Li-ren, Wan De-sen, Pan Zhi-zhong, Zhou Zhi-wei, Chen Gong, Wu Xiao-jun, Lu Zhen-hai, Ding Pei-rong

机构信息

Department of Abdominal Surgery, Cancer Center of Sun Yat-sen University, State Key Laboratory of Oncology in Sonthern China, Guangzhou 510060, China.

出版信息

Zhonghua Wei Chang Wai Ke Za Zhi. 2006 Sep;9(5):402-4.

PMID:17043960

Abstract

OBJECTIVE

To investigate the clinical features and treatment of anal canal adenocarcinoma.

METHODS

Clinical data of 49 patients with anal canal adenocarcinoma treated in our hospital from January 1965 to March 2002 were analyzed retrospectively.

RESULTS

The ratio of male to female was 1.3. The median age was 56 years old. Anal bleeding, tapering stool and anal lump were the most common symptoms. Chronic perianal diseases were complicated in 36.7% of the cases. The median follow-up was 66 months. Local recurrence and inguinal lymph node metastasis were found in 7 cases respectively, lung metastasis in 2, supraclavicular and mediastinal metastasis in 1 respectively. The 3-year survival rates in the patients with resection alone, radiochemotherapy alone, resection combined with radiochemotherapy, and without any treatment were 41.3%, 20.0%, 56.3% and 15.0%, respectively, and the 5-year survival rates were 34.4%, 0, 37.5%, 0, respectively.

CONCLUSIONS

Anal canal adenocarcinoma is a rare and fatal malignancy. Abdomino-perineal resection combined with postoperative radiochemotherapy is the principal treatment.

摘要

目的

探讨肛管腺癌的临床特征及治疗方法。

方法

回顾性分析1965年1月至2002年3月在我院治疗的49例肛管腺癌患者的临床资料。

结果

男女比例为1.3。中位年龄为56岁。肛门出血、大便变细和肛门肿物是最常见的症状。36.7%的病例合并慢性肛周疾病。中位随访时间为66个月。分别有7例发生局部复发和腹股沟淋巴结转移，2例发生肺转移，1例分别发生锁骨上和纵隔转移。单纯手术切除、单纯放化疗、手术联合放化疗及未接受任何治疗的患者3年生存率分别为41.3%、20.0%、56.3%和15.0%，5年生存率分别为34.4%、0、37.5%、0。