Templeton David J, Mao Limin, Prestage Garrett, Kaldor John M, Kippax Susan, Grulich Andrew E
Sex Health. 2006 Sep;3(3):191-3. doi: 10.1071/sh06009.
Male circumcision may reduce the risk of HIV acquisition in heterosexual men. In observational studies, confounding by demographic factors could produce spurious associations between circumcision and HIV risk. To assess this possibility, cross-sectional data on self-reported circumcision status and demographic factors were collected at baseline as part of the Health in Men study. Two-thirds of 1426 subjects were circumcised, mostly in the neonatal period. In multivariate analyses, age, ethnicity and country of birth were independently associated with circumcision status. Confounding by these demographic factors must be considered in future epidemiological studies addressing circumcision and HIV acquisition.
男性包皮环切术可能会降低异性恋男性感染艾滋病毒的风险。在观察性研究中，人口统计学因素造成的混杂情况可能会在包皮环切术与感染艾滋病毒风险之间产生虚假关联。为评估这种可能性，作为男性健康研究的一部分，在基线时收集了关于自我报告的包皮环切术状况和人口统计学因素的横断面数据。1426名研究对象中有三分之二接受了包皮环切术，大多是在新生儿期。在多变量分析中，年龄、种族和出生国家与包皮环切术状况独立相关。在未来针对包皮环切术与艾滋病毒感染的流行病学研究中，必须考虑这些人口统计学因素造成的混杂情况。
