Pichaiwong Warangkana, Leelahavanichkul Asada, Eiam-ong Somchai
Department of Medicine, Sirindhorn Hospital.
J Med Assoc Thai. 2006 Aug;89 Suppl 2:S65-72.
To compare the clearance performances and biocompatibility between the modified cellulose membrane and the standard synthetic membrane in continuous renal replacement therapy (CRRT).
Seventeen patients with acute renal failure (ARF) were treated with separated continuous veno venous hemofiltration (CVVH) system conducted with the pre-dilution mode. The modified cellulose used was a Sureflux150E (cellulose triacetate) and the standard synthetic membranes used was an AV-400. Blood and replacement flow rate were kept at 100 and 20 mL/min, respectively. Ultrafiltraion rate was 1,200 mL/hr. Samplings of blood and ultrafiltrate were collected at baseline, 2, 8, 16, and 24 hr.
Patients in both methods could similarly tolerate CRRT with only minor complications. Sureflux 150E and AV-400 provided comparable values of sieving coefficients and clearances of small solutes. The albumin loss in ultrafiltrate by Sureflux 150E was greater than AV-400. The values of life span and biocompatability of both hemofilters were not different.
Because of the excellent efficacy and the much cheaper cost, the modified cellulose membrane could be an appropriate alternative to standard synthetic membrane in CRRT.
比较改良纤维素膜与标准合成膜在连续性肾脏替代治疗（CRRT）中的清除性能和生物相容性。
17例急性肾衰竭（ARF）患者采用前稀释模式的间断连续性静脉-静脉血液滤过（CVVH）系统进行治疗。使用的改良纤维素为Sureflux150E（三醋酸纤维素），标准合成膜为AV-400。血液流速和置换液流速分别保持在100和20 mL/分钟。超滤率为1200 mL/小时。在基线、2、8、16和24小时采集血液和超滤液样本。
两种方法的患者对CRRT的耐受性相似，仅出现轻微并发症。Sureflux 150E和AV-400对小分子溶质的筛系数和清除率相当。Sureflux 150E超滤液中的白蛋白损失大于AV-400。两种血液滤过器的使用寿命和生物相容性值无差异。
由于疗效优异且成本低得多，改良纤维素膜可作为CRRT中标准合成膜的合适替代品。
