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肠内营养补充剂:膳食补充剂还是替代品?

[Enteral supplements: dietary supplements or substitutes?].

作者信息

Martínez Sogues M, Pons Busom M, Roca Rossellini N, Aguas Compaired M, Eguileor Partearroyo B

机构信息

Servicio de Farmacia, Hospital Universitario Sagrat Cor, Barcelona, España.

出版信息

Nutr Hosp. 2006 Sep-Oct;21(5):581-90.

Abstract

OBJECTIVE

To assess the use of oral nutritional supplements analyzing the reason for prescription and its implication in caloric-protein intake.

SETTING

study performed at a university hospital of 350 beds with medical and surgical specialties. SUBJECTS, PATIENTS: Patients inclusion was done by selecting all starting oral nutritional supplement prescription. Exclusion criteria were being younger than 18 years, being admitted to the Intensive Care Unit, having cognition or communication impairments, being on concomitant parenteral nutrition or requiring complete enteral diet, and/or using nasogastric tube for feeding. We also excluded special enteral diets, specifically designed for certain conditions.

INTERVENTIONS

One-year long prospective study on prescription of oral nutritional supplements. Through clinical chart review and personal interview, we recorded demographic data, nutritional parameters, characteristics of the diet and supplement, and caloricprotein intake prescribed and ingested. The data were introduced in an Access97 database and processed by means of SPSS software for Windows. We performed a descriptive study of quantitative and qualitative variables, a chi2 analysis between qualitative variables, and a comparative analysis between means of all paired data by means of the student's t test, and variance analysis between quantitative variables. The significance level was set at p < 0.05.

RESULTS

we were only able to analyze 77 out of 130 prescriptions for nutritional supplements since we could not adequately interview the remaining patients, mainly due to neurological impairments. Mean age was 74.8 years (SD = 12) and 50.6% were women. The departments prescribing the highest number of supplements were hematology (22.1%) and internal medicine (20.8%). GI neoplasm was the most frequent diagnosis at admission (27.3%). The most frequent indication was kwashiorkor (45.5%), with 15.6% of patients being well nourished. Mean therapy duration was 11 days (SD = 11.1), and the main reason for termination was hospital discharge (70.1%). The supplement was concomitantly prescribed with the meals in 70.6% of the cases, and more than half of the patients (70.1%) liked it, the most frequently prescribed was as a cream (61%) and the best accepted being as a liquid (78%). The average daily caloric load ingested with the foods of the hospital diet was similar between the first an third days of supplement prescription (p = 0.879) and the first and seventh days (p = 0.499). So happened when analyzing protein intake. With the supplement administration, there was a significant increase in patients' caloric intake from 310 Kcal at the third day to 337 Kcal at the seventh day (p < 0.0005) in both cases. Similar results were obtained when assessing total protein load ingested (p < 0.0005).

CONCLUSIONS

Nutritional supplements are correctly used in most of the cases. They allow for a significant increase in the protein-caloric intake with no modification of hospital diet, becoming an appropriate nutritional source when the diet is insufficient.

摘要

目的

通过分析口服营养补充剂的处方原因及其对热量 - 蛋白质摄入的影响,评估其使用情况。

背景

研究在一家拥有350张床位、设有内科和外科专业的大学医院进行。

研究对象

通过选择所有开始口服营养补充剂处方的患者纳入研究。排除标准为年龄小于18岁、入住重症监护病房、有认知或沟通障碍、正在接受肠外营养或需要完全肠内营养,和/或使用鼻胃管喂养。我们还排除了专门为某些特定情况设计的特殊肠内饮食。

干预措施

对口服营养补充剂处方进行为期一年的前瞻性研究。通过临床病历审查和个人访谈,我们记录了人口统计学数据、营养参数、饮食和补充剂的特征,以及规定和摄入的热量 - 蛋白质摄入量。数据录入Access97数据库,并使用Windows版SPSS软件进行处理。我们对定量和定性变量进行描述性研究,对定性变量进行卡方分析,通过学生t检验对所有配对数据的均值进行比较分析,并对定量变量进行方差分析。显著性水平设定为p < 0.05。

结果

由于主要因神经功能障碍而无法充分访谈其余患者,我们仅能分析130份营养补充剂处方中的77份。平均年龄为74.8岁(标准差 = 12),女性占50.6%。开出补充剂数量最多的科室是血液科(22.1%)和内科(20.8%)。入院时最常见的诊断是胃肠道肿瘤(27.3%)。最常见的适应证是夸希奥科病(45.5%),15.6%的患者营养状况良好。平均治疗持续时间为11天(标准差 = 11.1),终止治疗的主要原因是出院(70.1%)。70.6%的病例中补充剂与餐食同时开具,超过一半的患者(70.1%)喜欢它,最常开具的剂型是乳膏(61%),最易接受的是液体剂型(78%)。在补充剂处方的第一天和第三天之间(p = 0.879)以及第一天和第七天之间(p = 0.499),医院饮食中摄入的平均每日热量负荷相似。蛋白质摄入分析时情况相同。补充剂给药后,两种情况下患者的热量摄入均显著增加,从第三天的310千卡增加到第七天的337千卡(p < 0.0005)。评估总蛋白质摄入量时也获得了类似结果(p < 0.0005)。

结论

大多数情况下营养补充剂使用正确。它们能在不改变医院饮食的情况下显著增加蛋白质 - 热量摄入,在饮食不足时成为合适的营养来源。

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