Gazi Irene F, Elisaf Moses
Int J Cardiol. 2007 Jul 31;119(3):414-5. doi: 10.1016/j.ijcard.2006.07.139. Epub 2006 Oct 11.
The present study compares the low-density lipoprotein cholesterol (LDL-C) values obtained by the Friedewald formula (LDL-F) with those derived from a new equation that uses only the concentrations of total cholesterol and triglycerides (LDL-A) in patients with the metabolic syndrome (MS) (n=118) and in age- and sex-matched controls (n=112). According to our results, LDL-A was correlated with LDL-F in the MS as well as in the control group (p for both <0.001). However, LDL-A slightly overestimated the LDL-C levels compared with LDL-F in the control group, possible due to the higher high-density lipoprotein cholesterol (HDL-C) levels in these individuals. Importantly, no difference was observed between the two equations in the MS group. LDL-A may be useful for the calculation of LDL-C levels when HDL-C level are not easily available.
本研究比较了代谢综合征（MS）患者（n = 118）和年龄及性别匹配的对照组（n = 112）中，通过Friedewald公式（LDL-F）得出的低密度脂蛋白胆固醇（LDL-C）值与仅使用总胆固醇和甘油三酯浓度的新公式（LDL-A）得出的LDL-C值。根据我们的结果，MS组和对照组中LDL-A与LDL-F均相关（两者p均<0.001）。然而，与LDL-F相比，对照组中LDL-A略微高估了LDL-C水平，这可能是由于这些个体中高密度脂蛋白胆固醇（HDL-C）水平较高所致。重要的是，MS组中两个公式之间未观察到差异。当不易获得HDL-C水平时，LDL-A可能有助于计算LDL-C水平。
