alpha-Amino acid derivatives as proton pump inhibitors and potent anti-ulcer agents.
作者信息
Sharma Preeti, Singh Sangeeta, Siddiqui Tanveer I, Singh Vishnu S, Kundu Bijoy, Prathipati Philip, Saxena Anil K, Dikshit Dinesh K, Rastogi Leena, Dixit Chetna, Gupta M B, Patnaik G K, Dikshit Madhu
机构信息
Medicinal Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India.
出版信息
Eur J Med Chem. 2007 Mar;42(3):386-93. doi: 10.1016/j.ejmech.2006.08.016. Epub 2006 Oct 11.
PMID:17045703
Abstract
In a program to identify new anti-ulcer compounds, a series of N-acyl derivatives of alpha-amino acids were screened for their in vitro H(+)/K(+) ATPase inhibitory activity, and in vivo efficacy in Pylorus ligation model. 3D-QSAR studies were carried out and a representative compound 13 was studied for the nature of its proton pump inhibition.
摘要
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