Stern Claudio D
Department of Anatomy & Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Curr Opin Cell Biol. 2006 Dec;18(6):692-7. doi: 10.1016/j.ceb.2006.09.002. Epub 2006 Oct 11.
Neural induction is the process by which embryonic cells in the ectoderm make a decision to acquire a neural fate (to form the neural plate) rather than give rise to other structures such as epidermis or mesoderm. An influential model proposed a decade ago, the 'default model', postulated that ectodermal cells will become neurons if they receive no signals at all, but that this is normally inhibited in prospective epidermal cells by the action of bone morphogenetic proteins. Recent results now reveal considerable more complexity and emphasis is shifting from intercellular signalling factors to trying to understand the regulation of expression of key genes within the nucleus.
神经诱导是外胚层中的胚胎细胞决定获得神经命运（形成神经板）而不是产生其他结构（如表皮或中胚层）的过程。十年前提出的一个有影响力的模型，即“默认模型”，假定外胚层细胞如果完全不接收信号就会变成神经元，但在预期的表皮细胞中，这种情况通常会受到骨形态发生蛋白作用的抑制。现在的最新结果显示出相当大的复杂性，重点正从细胞间信号因子转向试图理解细胞核内关键基因表达的调控。
