Moyron-Quiroz Juan E, Rangel-Moreno Javier, Hartson Louise, Kusser Kim, Tighe Michael P, Klonowski Kimberly D, Lefrançois Leo, Cauley Linda S, Harmsen Allen G, Lund Frances E, Randall Troy D
Trudeau Institute, Saranac Lake, New York 12983, USA.
Immunity. 2006 Oct;25(4):643-54. doi: 10.1016/j.immuni.2006.08.022.
Secondary lymphoid organs (SLOs) promote primary immune responses by recruiting naive lymphocytes and activated APCs. However, their role in the persistence or responsiveness of memory lymphocytes is unclear. We tested whether memory cells were maintained and could respond to challenge in the absence of SLOs. We found that influenza-specific CD8 cells in the lung acquired a memory phenotype, underwent homeostatic proliferation, recirculated through nonlymphoid tissues, and responded to and cleared a challenge infection in the complete absence of SLOs. Similarly, influenza-specific virus-neutralizing antibody was generated and maintained in the absence of SLOs. Inducible bronchus-associated lymphoid tissue (iBALT) was also formed in the lungs of previously infected mice and may provide a niche for the maintenance of memory cells at the local level. These data show that SLOs are dispensable for the maintenance of immunologic memory and directly demonstrate the utility of local tissues, such as iBALT, in secondary immune responses.
次级淋巴器官（SLOs）通过募集初始淋巴细胞和活化的抗原呈递细胞（APCs）来促进初级免疫反应。然而，它们在记忆淋巴细胞的持久性或反应性方面的作用尚不清楚。我们测试了在没有SLOs的情况下记忆细胞是否能维持并对刺激作出反应。我们发现，肺中的流感特异性CD8细胞获得了记忆表型，经历了稳态增殖，通过非淋巴组织再循环，并在完全没有SLOs的情况下对刺激感染作出反应并清除感染。同样，在没有SLOs的情况下也能产生并维持流感特异性病毒中和抗体。在先前感染小鼠的肺中还形成了可诱导的支气管相关淋巴组织（iBALT），它可能为在局部水平维持记忆细胞提供一个微环境。这些数据表明，SLOs对于维持免疫记忆并非必需，并直接证明了局部组织，如iBALT，在次级免疫反应中的作用。
