Banham Alison H
LRF Lymphoma Antigens Group, Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
Trends Immunol. 2006 Dec;27(12):541-4. doi: 10.1016/j.it.2006.10.002. Epub 2006 Oct 12.
FOXP3+ regulatory T (Treg) cells have crucial roles in maintaining self-tolerance and modulating adaptive immune responses. Functional studies of Treg cells have been hampered by a lack of suitable cell-surface markers that specifically enable their purification without contamination by non-regulatory CD25+ effector T cells. Two recent studies have demonstrated that downregulation of the interleukin-7 receptor (CD127) distinguishes Treg cells from activated T cells, facilitating both Treg-cell purification and their functional characterization in human diseases. CD127 uniquely enables the purification of FOXP3+ Treg cells and, potentially, also "adaptive" regulatory T-cell subsets from the CD4+CD25- T-cell population.
FOXP3⁺调节性T（Treg）细胞在维持自身耐受性和调节适应性免疫反应中起关键作用。由于缺乏合适的细胞表面标志物，无法特异性地纯化Treg细胞而不被非调节性CD25⁺效应T细胞污染，Treg细胞的功能研究受到了阻碍。最近的两项研究表明，白细胞介素-7受体（CD127）的下调可将Treg细胞与活化T细胞区分开来，有助于在人类疾病中纯化Treg细胞及其功能表征。CD127独特地能够从CD4⁺CD25⁻T细胞群体中纯化FOXP3⁺Treg细胞，以及潜在地纯化“适应性”调节性T细胞亚群。
