Metoki Ryo, Moriyasu Fuminori, Kamiyama Naohisa, Sugimoto Katsutoshi, Iijima Hiroko, Xu Hui-Xiong, Aoki Takaya, Miyata Yuki, Yamamoto Kei, Kudo Kosei, Shimizu Masafumi, Yamada Masahiko
The Fourth Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
Ultrasound Med Biol. 2006 Oct;32(10):1459-66. doi: 10.1016/j.ultrasmedbio.2006.06.004.
Flash-replenishment (FR) utilizes destruction of microbubbles in the scan volume by high-power ultrasound and enables to observe reperfusion at a low acoustic power. In this paper, we introduced theoretic equation between probability density function (PDF) of the transit time in the scan volume and time intensity curve (TIC) measured by FR method. From the equations, it was explained that the mean transit time (MTT) through the scan volume was calculated from the plateau level and tangent of the initial slope. Animal experiments were also performed to measure TIC in the parenchymal region of the liver using FR method. From the result of the TIC, the variant of the PDF for the transit time was found to be small and the average MTT was 11.1 s. Hepatic blood flow by an ultrasonic transit time flowmeter was also measured in the same experiment, and adequate correlation was obtained from between the two methods. The results suggested that the FR method, which is a noninvasive measurement, can predict the blood flow of the liver.
快速补充（FR）利用高功率超声破坏扫描区域内的微泡，并能够在低声功率下观察再灌注情况。在本文中，我们介绍了扫描区域内通过时间的概率密度函数（PDF）与采用FR方法测量的时间强度曲线（TIC）之间的理论方程。从这些方程可以看出，通过扫描区域的平均通过时间（MTT）是根据平台期水平和初始斜率的切线计算得出的。还进行了动物实验，采用FR方法测量肝脏实质区域的TIC。根据TIC的结果，发现通过时间的PDF变化很小，平均MTT为11.1秒。在同一实验中还使用超声通过时间流量计测量了肝血流量，两种方法之间获得了良好的相关性。结果表明，FR方法这种非侵入性测量方法能够预测肝脏血流量。
