Karagueuzian H S, Khan S S, Mandel W J, Hong K, Diamond G A
Cedars-Sinai Medical Center, Department of Medicine, UCLA 90048.
Pacing Clin Electrophysiol. 1990 Dec;13(12 Pt 2):2113-8. doi: 10.1111/j.1540-8159.1990.tb06953.x.
Rate-dependent bifurcations and aperiodic changes in action potential duration and amplitude were observed in periodically stimulated cardiac Purkinje and ventricular muscle cells isolated from dogs with quinidine-induced ventricular fibrillation and ventricular tachycardia. The slope of the action potential duration restitution curve was higher in the quinidine intoxicated fibers than in normal untreated fibers. Aperiodicity and bifurcations in action potential duration (APD) could not be observed in normal untreated cardiac fibers. The data suggest that induction of reentrant ventricular fibrillation and ventricular tachycardia could be brought about not by fixed but rather by changing alterations in cellular electrical activity. Theory based on nonlinear dynamics seems to provide a quantitative basis for such an analysis. This could have important implications in the issue of sudden cardiac death, a major problem in cardiology.
在从患有奎尼丁诱发的室颤和室速的犬分离出的周期性刺激的心脏浦肯野细胞和心室肌细胞中，观察到了速率依赖性分叉以及动作电位持续时间和幅度的非周期性变化。奎尼丁中毒纤维中动作电位持续时间恢复曲线的斜率高于正常未处理纤维。在正常未处理的心脏纤维中未观察到动作电位持续时间（APD）的非周期性和分叉。数据表明，折返性室颤和室速的诱发可能不是由固定的而是由细胞电活动的变化改变引起的。基于非线性动力学的理论似乎为这种分析提供了定量基础。这可能对心脏性猝死问题具有重要意义，心脏性猝死是心脏病学中的一个主要问题。
