Aslan Erdogan, Bagis Tayfun, Kilicdag Esra Bulgan, Tarim Ebru, Erkanli Serkan, Kuscu Esra
Baskent University, School of Medicine, Department of Obstetrics and Gynecology, Adana Seyhan Hospital, Turkey.
Maturitas. 2007 Jan 20;56(1):78-83. doi: 10.1016/j.maturitas.2006.06.006. Epub 2006 Oct 13.
To evaluate the differences between the immediate and tapered cessation protocols of hormone therapy in terms of recurrence of menopausal symptoms.
In this prospective, randomized clinical study 70 consecutive patients in whom hormone therapy was no longer preferred were recruited from the menopause clinic of a university hospital and rank randomized into two groups. In group 1 (n=35) hormone therapy was immediately discontinued and in group 2 (n=35) the medication was tapered. Every patient was questioned about vasomotor symptoms before the initiation of hormone therapy at the first visit, and then revisited at the end of 2 and 4 weeks.
We did not find any statistically significant difference between two protocols in terms of symptom severity and frequency at the end of 2 and 4 weeks of discontinuation. Although statistically insignificant, the symptoms tended to recur in fewer patients and in a less severe form in both groups when compared with their pretreatment status.
Tapering or immediate discontinuing of hormone therapy did not affect the recurrence rate and severity of menopausal symptoms at the end of 4 weeks.
评估激素治疗的即刻停药方案与逐渐减量停药方案在绝经症状复发方面的差异。
在这项前瞻性随机临床研究中，从一所大学医院的更年期诊所连续招募了70例不再适合接受激素治疗的患者，并将其随机分为两组。第1组（n = 35）立即停用激素治疗，第2组（n = 35）逐渐减量停药。每位患者在首次就诊开始激素治疗前均被询问血管舒缩症状，然后在停药2周和4周结束时再次就诊。
在停药2周和4周结束时，两种方案在症状严重程度和频率方面均未发现任何统计学上的显著差异。尽管无统计学意义，但与治疗前状态相比，两组中症状复发的患者较少，且症状较轻。
激素治疗逐渐减量或即刻停药在4周结束时均不影响绝经症状的复发率和严重程度。
