Rock Kenneth L
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
Immunity. 2006 Oct;25(4):523-5. doi: 10.1016/j.immuni.2006.09.003.
How are extracellular proteins cross-presented on MHC class I molecules? In this issue of Immunity, demonstrate that the ER-associated degradation (ERAD) export pathway operates in the phagosomes of dendritic cells and transfers antigens into the MHC class I pathway.
细胞外蛋白质是如何在MHC I类分子上进行交叉呈递的?在本期《免疫》杂志中,证明内质网相关降解(ERAD)输出途径在树突状细胞的吞噬体中起作用,并将抗原转移到MHC I类途径中。