Monu Ngozi, Trombetta E Sergio
Cancer Institute, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA.
Curr Opin Immunol. 2007 Feb;19(1):66-72. doi: 10.1016/j.coi.2006.11.017. Epub 2006 Dec 6.
Cross-presentation of exogenous proteins on MHC class I complexes contributes to the priming CD8(+) T-cell responses. However, the mechanisms by which antigen-presenting cells transfer internalized proteins to the MHC class I loading pathway are not well understood. Endocytosed proteins often appear to require proteasomal processing and transport into the endoplasmic reticulum, but the intracellular routes involved in cross-presentation remain unclear. Understanding the molecular and cellular basis of cross-presentation will illuminate novel aspects of cell physiology and might lead to improved vaccine design.
外源性蛋白质在MHC I类复合物上的交叉呈递有助于启动CD8(+) T细胞反应。然而，抗原呈递细胞将内化蛋白质转移至MHC I类装载途径的机制尚不清楚。内吞的蛋白质似乎通常需要蛋白酶体加工并转运至内质网，但交叉呈递所涉及的细胞内途径仍不明确。了解交叉呈递的分子和细胞基础将揭示细胞生理学的新方面，并可能有助于改进疫苗设计。
