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First highly stereoselective synthesis of anti-alpha-trifluoromethyl-beta-amino acid derivatives.

作者信息

Shimada Taichi, Yoshioka Masamitsu, Konno Tsutomu, Ishihara Takashi

机构信息

Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-8585, Japan.

出版信息

Chem Commun (Camb). 2006 Sep 14(34):3628-30. doi: 10.1039/b603882d. Epub 2006 Jul 26.

DOI:10.1039/b603882d
PMID:17047787
Abstract

The Reformatsky-type reaction of 2-bromo-3,3,3-trifluoropropanoic imide with various types of imines, in the presence of ZnBr2 as a Lewis acid in THF at 0 degrees C for 3 h, gave the corresponding alpha-trifluoromethyl-beta-amino acid derivatives in a highly anti-selective manner.

摘要

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