Watterson James
Department of Forensic Science, Laurentian University, 935 Ramsey Lake Rd., Sudbury, Ontario, Canada P3E 2C6.
Analyst. 2006 Sep;131(9):961-5. doi: 10.1039/b609130j. Epub 2006 Jul 20.
Forensic toxicologists typically work with body fluids such as blood or urine, as well as visceral tissues such as liver. Very little work has been done to properly understand the utility of drug concentrations in bone tissue in a toxicologic examination. Literature reports suggest that detection of selected drugs in bone tissues is possible, but challenging work remains to determine the implications of bone tissue drug concentration measurements with respect to time lines of drug ingestion and deposition into bone, tissue sampling and sensitivity requirements, and environmental effects on measurements and their interpretation.
法医毒理学家通常处理血液或尿液等体液，以及肝脏等内脏组织。在毒理学检查中，为正确理解骨组织中药物浓度的效用所做的工作很少。文献报告表明，在骨组织中检测特定药物是可能的，但仍有具有挑战性的工作要做，即确定骨组织药物浓度测量对于药物摄入和沉积到骨中的时间线、组织采样和灵敏度要求以及测量及其解释的环境影响的意义。
