Lin Yingsong, Kikuchi Shogo, Tamakoshi Akiko, Kawamura Takashi, Inaba Yutaka, Kurosawa Michiko, Motohashi Yutaka, Yagyu Kiyoko, Obata Yuki, Ishibashi Teruo
Department of Public Health, Aichi Medical University School of Medicine, 21 Karimata, Yazako, Nagakute, Aichi-gun, Aichi 480-1195, Japan.
J Gastroenterol. 2006 Sep;41(9):878-83. doi: 10.1007/s00535-006-1869-z.
The etiology of pancreatic cancer remains largely unknown. We examined the association of pancreatic cancer deaths with menstrual and reproductive factors in a cohort study involving Japanese women.
A total of 63,273 women were followed up for mortality from 1988 to 1999. Information on menstrual and reproductive factors was obtained by a questionnaire survey at baseline. Cox proportional-hazards models were used to estimate the relative risks (RRs) and 95% confidence intervals (CIs) for death from pancreatic cancer in relation to menstrual and reproductive factors.
During 631,401 person-years of follow-up, 154 women died from pancreatic cancer. Parity was not significantly associated with the risk of death from pancreatic cancer; the RR was 0.80 (95% CI, 0.31-2.11) for women with six or more births compared with women with zero or one birth. We found no significant overall association with other reproductive factors, including pregnancy, age at first birth, and menopause. The risk appeared to increase with increasing age at menarche; the RR was 1.49 (95% CI, 0.95-2.34) for women who had menarche after 16 years of age compared to those who had menarche before they were 15 years old.
Our prospective data indicate that menstrual and reproductive factors are not associated with the risk of death from pancreatic cancer among Japanese women.
胰腺癌的病因在很大程度上仍然未知。我们在一项涉及日本女性的队列研究中，研究了胰腺癌死亡与月经和生殖因素之间的关联。
对总共63273名女性进行了1988年至1999年的死亡随访。月经和生殖因素的信息通过基线时的问卷调查获得。使用Cox比例风险模型来估计与月经和生殖因素相关的胰腺癌死亡的相对风险（RRs）和95%置信区间（CIs）。
在631401人年的随访期间，有154名女性死于胰腺癌。产次与胰腺癌死亡风险无显著关联；与生育零次或一次的女性相比，生育六次或更多次的女性的RR为0.80（95%CI，0.31 - 2.11）。我们发现与其他生殖因素，包括怀孕、初产年龄和绝经，无显著的总体关联。风险似乎随着初潮年龄的增加而增加；与15岁之前初潮的女性相比，16岁之后初潮的女性的RR为1.49（95%CI，0.95 - 2.34）。
我们的前瞻性数据表明，月经和生殖因素与日本女性胰腺癌死亡风险无关。
