Wang Michael M
Department of Neurology and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Semin Neurol. 2006 Nov;26(5):523-30. doi: 10.1055/s-2006-951625.
Ischemic stroke has long been thought to have a genetic component that is independent of conventional vascular risk factors. It has been estimated that over one half of stroke risk is determined by inherited genes. However, until recently, strong evidence of genetic influence on ischemic stroke has been subject to criticism because the risk factors for stroke are also inherited and because previous studies suffered from limitations imposed by this highly heterogeneous neurological disorder. Recent advances in molecular genetics have led to the identification of specific genetic loci that impart susceptibility to ischemic stroke. We review the studies of these genes and discuss the future potential applications of genetic markers on the management of ischemic stroke patients.
长期以来，人们一直认为缺血性中风具有独立于传统血管危险因素的遗传成分。据估计，超过一半的中风风险由遗传基因决定。然而，直到最近，关于遗传因素对缺血性中风影响的有力证据一直受到批评，因为中风的危险因素也是可遗传的，而且以往的研究受到这种高度异质性神经疾病所带来的局限性的影响。分子遗传学的最新进展已导致发现了赋予缺血性中风易感性的特定基因位点。我们回顾了这些基因的研究，并讨论了基因标记物在缺血性中风患者管理中的未来潜在应用。
