Spangenberg H C, Blum H E
Medizinische Universitätsklinik, Abteilung Innere Medizin II, Albert-Ludwigs-Universität Freiburg.
Praxis (Bern 1994). 2006 Oct 4;95(40):1557-62. doi: 10.1024/1661-8157.95.40.1557.
Extrahepatic manifestations of liver diseases especially the hepatitis B virus (HBV)-infection and hepatitis C virus (HCV)-infection may occur during acute and/or chronic viral hepatitis. Besides a serum like illness with fever, arthralgia and urticaria, haematological disorders with transient bone marrow suppression and cryoglobulinemia have been described. Vasculitis is a rare complication of viral hepatitis. However, HCV can trigger a cryoglobulinemic vasculitis and may clinically present with purpura, arthritis, neuropathy, glomerulonephritis and fatigue. Panarteritis nodosa is frequently associated with HBV infection, which is caused by deposits of immune complexes in the arterial wall. Therapy of both types of vasculitis depends on the severity of disease and may include immunosuppressive agents as well as antivirals.
肝脏疾病的肝外表现，尤其是乙型肝炎病毒（HBV）感染和丙型肝炎病毒（HCV）感染，可能在急性和/或慢性病毒性肝炎期间出现。除了类似血清病的症状，如发热、关节痛和荨麻疹外，还描述了伴有短暂骨髓抑制和冷球蛋白血症的血液系统疾病。血管炎是病毒性肝炎的一种罕见并发症。然而，HCV可引发冷球蛋白血症性血管炎，临床上可能表现为紫癜、关节炎、神经病变、肾小球肾炎和疲劳。结节性多动脉炎常与HBV感染相关，这是由免疫复合物在动脉壁沉积所致。两种类型血管炎的治疗取决于疾病的严重程度，可能包括免疫抑制剂以及抗病毒药物。
