Taksaphan Sukanya, Kleebkaew Pilaiwan, Komwilaisak Rattana, Kiatchoosakun Pakaphan, Jirapradittha Junya, Ratanasiri Thawalwong
Department of Pediatrics, Khon Kaen University, Khon Kaen, Thailand.
J Med Assoc Thai. 2006 Aug;89(8):1277-86.
An intrauterine parvovirus B19 infection can result in severe fetal anemia and hydrops fetalis, which can lead to death. A case of fetal hydrops, diagnosed at 31 weeks gestation, is reported Cordocentesis revealed fetal hemoglobin of 5 g/dL. Due to fetal distress 18 hours later, the baby was delivered by emergency cesarean section and died two days later. Characteristic intra-nuclear inclusions in nucleated red blood cells were found in histopathological examinations of the liver and placenta, which supported the diagnosis of parvovirus B19 infection. Literatures about parvovirus B19 infection, especially intrauterine infection, its effects on the fetus, methods of diagnosis and management, were reviewed.
宫内细小病毒B19感染可导致严重的胎儿贫血和胎儿水肿，进而可能导致死亡。本文报告1例妊娠31周时诊断为胎儿水肿的病例。脐血穿刺显示胎儿血红蛋白为5 g/dL。18小时后因胎儿窘迫，该婴儿通过紧急剖宫产分娩，两天后死亡。在肝脏和胎盘的组织病理学检查中发现有核红细胞内有特征性的核内包涵体，这支持了细小病毒B19感染的诊断。本文回顾了有关细小病毒B19感染，尤其是宫内感染、其对胎儿的影响、诊断和处理方法的文献。
