Tirakunwichcha Suppapong, Tulvatana Wasee
Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Patumwan, Bangkok, Thailand.
J Med Assoc Thai. 2006 Aug;89(8):1318-21.
To study the histopathological findings of basaloid adenoid cystic carcinoma after high dose orbital irradiation.
The histopathology study was done in a 38-year-old Thai female patient who had basaloid adenoid cystic carcinoma of the right lacrimal gland confirmed by incisional biopsy. After a 60-Gy external irradiation, the mass decreased in size and finally could not be palpated, but subsequent orbital imaging still showed infiltrative soft tissue mass at the right lacrimal gland with bony defects at posterosuperior and lateral walls without extraorbital extension. Orbital exenteration and lateral orbitectomy was performed. The specimen was submitted for histopathological examination.
Microscopic examination revealed periglandular infiltration with chronic inflammation of the palpebral lobe of lacrimal gland. The orbital lobe was extensively replaced with fibrous tissue. There was only a small area of cribiform pattern of the adenoid cystic carcinoma left; no basaloid pattern was seen in the tissue.
The primitive cells (basaloid pattern) disappear after orbital irradiation for adenoid cystic carcinoma of the lacrimal gland. Replacement with fibrous tissue is seen.
研究高剂量眼眶照射后基底样腺样囊性癌的组织病理学表现。
对一名38岁泰国女性患者进行组织病理学研究，该患者经切开活检确诊为右侧泪腺基底样腺样囊性癌。60 Gy外照射后，肿块体积减小，最终无法触及，但随后的眼眶影像学检查仍显示右侧泪腺有浸润性软组织肿块，后上壁和外侧壁有骨质缺损，无眶外扩展。行眼眶内容剜除术和外侧眶切除术。将标本送检进行组织病理学检查。
显微镜检查显示泪腺睑叶腺周有慢性炎症浸润。眶叶被纤维组织广泛替代。仅残留小面积腺样囊性癌筛状结构；组织中未见基底样结构。
泪腺腺样囊性癌眼眶照射后原始细胞（基底样结构）消失，可见纤维组织替代。
