苯酚衍生物引发的三取代氮杂环丙烷开环反应：手性叔烷基-芳基醚的立体和区域选择性形成
Trisubstituted aziridine ring-opening by phenol derivatives: stereo- and regioselective formation of chiral tertiary alkyl-aryl ethers.
作者信息
Li Pixu, Forbeck Erin M, Evans Cory D, Joullié Madeleine M
机构信息
Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA.
出版信息
Org Lett. 2006 Oct 26;8(22):5105-7. doi: 10.1021/ol062010w.
PMID:17048854
Abstract
An unprecedented stereo- and regioselective trisubstituted aziridine ring-opening by phenol derivatives was discovered. The reaction features very mild reaction conditions and broad functional group compatibility, which provides a good method for the stereoselective formation of tertiary alkyl-aryl ethers in highly functionalized systems. [reaction: see text]
摘要
发现了一种前所未有的苯酚衍生物对三取代氮杂环丙烷的立体和区域选择性开环反应。该反应具有非常温和的反应条件和广泛的官能团兼容性，为在高度官能化体系中立体选择性地形成叔烷基-芳基醚提供了一种好方法。[反应：见正文]
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