通过保护基团诱导的芳香族寡酰胺解折叠来改进折叠体合成。

Improving foldamer synthesis through protecting group induced unfolding of aromatic oligoamides.

作者信息

Zhang Aimin, Ferguson Joseph S, Yamato Kazuhiro, Zheng Chong, Gong Bing

机构信息

Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

出版信息

Org Lett. 2006 Oct 26;8(22):5117-20. doi: 10.1021/ol062103d.

DOI:10.1021/ol062103d

PMID:17048857

Abstract

The hydrogen bond rigidified backbones of aromatic oligoamides are temporarily interrupted by replacing the amide hydrogens with the acid-labile 2,4-dimethoxybenzyl (DMB) group, which allows the efficient preparation of long folding oligomers that, upon removal of the DMB groups, fold into multiturn helices. [structure: see text]

摘要

通过用酸不稳定的2,4 - 二甲氧基苄基（DMB）基团取代酰胺氢，芳香族低聚酰胺的氢键刚性主链会暂时中断，这使得能够高效制备长折叠低聚物，这些低聚物在去除DMB基团后会折叠成多圈螺旋。[结构：见正文]