Cai Chaoxian, Rivera Nelo R, Balsells Jaume, Sidler Rick R, McWilliams J Christopher, Shultz C Scott, Sun Yongkui
Process Research, Merck Research Laboratories, Merck & Company, Inc., P. O. Box 2000, Rahway, NJ 07065, USA.
Org Lett. 2006 Oct 26;8(22):5161-4. doi: 10.1021/ol062208g.
Aryl carboxylic esters were synthesized by Pd-catalyzed carbonylation of aryl p-fluorobenzenesulfonates or -tosylates. A unique Josiphos ligand was discovered through high-throughput catalyst screening, which was the key for the successful carbonylation of various substrates. This catalyst is effective and works well for both electron-rich and electron-poor aryl arenesulfonates. Isolated yields of up to 90% were obtained for aryl p-fluorobenzenesulfonates and -tosylates. [reaction: see text]
通过钯催化芳基对氟苯磺酸盐或对甲苯磺酸盐的羰基化反应合成了芳基羧酸酯。通过高通量催化剂筛选发现了一种独特的Josiphos配体，这是各种底物成功进行羰基化反应的关键。该催化剂对富电子和缺电子的芳基芳基磺酸盐均有效且效果良好。芳基对氟苯磺酸盐和对甲苯磺酸盐的分离产率高达90%。[反应：见正文]
