Sato Nao, Ono Kentaro, Haga Kensuke, Yokota Makoto, Inenaga Kiyotoshi
Department of Biosciences, Kyushu Dental College, 2-6-1 Manazuru, Fukuoka 803-8580, Japan.
Arch Oral Biol. 2007 Jan;52(1):26-9. doi: 10.1016/j.archoralbio.2006.09.002. Epub 2006 Oct 17.
Intraperitoneal injection of a sialogogue, pilocarpine, at high concentrations induces salivation via peripheral pathways and thirst sensation via central pathways. In this study, we report that the effects of another sialagogue, cevimeline, on salivation and water intake in conscious rats differ from those of pilocarpine.
We investigated that effects of peripherally and centrally injected cevimeline on parotid saliva flow rate and water intake in conscious rats. The results were compared with those of pilocarpine.
The intraperitoneal injection of cevimeline induced salivation from the parotid gland, but not water intake. In contrast, the intracerebroventricular injection of cevimeline induced water intake without salivation. The concentration of cevimeline needed to induce salivation by intraperitoneal injection was several 10 times that of pilocarpine, but that needed to induce water intake by intracerebroventricular injection was over a 1000 times greater.
The finding that intraperitoneally injected cevimeline induces salivation without inducing water intake, suggests that the effects on the thirst center in the brain are weaker than those of pilocarpine.
高浓度腹腔注射唾液分泌促进剂毛果芸香碱可通过外周途径诱导唾液分泌，并通过中枢途径引起口渴感。在本研究中，我们报告了另一种唾液分泌促进剂西维美林对清醒大鼠唾液分泌和水摄入量的影响与毛果芸香碱不同。
我们研究了外周和中枢注射西维美林对清醒大鼠腮腺唾液流速和水摄入量的影响。并将结果与毛果芸香碱的结果进行比较。
腹腔注射西维美林可诱导腮腺唾液分泌，但不会引起水摄入。相反，脑室内注射西维美林会引起水摄入但不会引起唾液分泌。腹腔注射诱导唾液分泌所需的西维美林浓度是毛果芸香碱的几十倍，但脑室内注射诱导水摄入所需的浓度则高出一千多倍。
腹腔注射西维美林可诱导唾液分泌而不引起水摄入，这一发现表明其对脑内口渴中枢的作用比毛果芸香碱弱。
