Mendez Pablo, Wandosell Francisco, Garcia-Segura Luis M
Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), E-28002 Madrid, Spain.
Front Neuroendocrinol. 2006 Dec;27(4):391-403. doi: 10.1016/j.yfrne.2006.09.001. Epub 2006 Oct 16.
Accumulating evidence suggests that insulin-like growth factor-I (IGF-I) and estradiol interact to regulate neural function. In this review, we focus on the cellular and molecular mechanisms involved in this interaction. The expression of estrogen receptors (ERs) and IGF-I receptor is cross-regulated in the central nervous system and many neurons and astrocytes coexpress both receptors. Furthermore, estradiol activates IGF-I receptor and its intracellular signaling. This effect may involve classical ERs since recent findings suggest that ERalpha may affect IGF-I actions in the brain by a direct interaction with some of the components of IGF-I signaling. In turn, IGF-I may regulate ER transcriptional activity in neuronal cells. In conclusion, ERs appear to be part of the signaling mechanism of IGF-I, and IGF-I receptor part of the mechanism of estradiol signaling in the nervous system.
越来越多的证据表明，胰岛素样生长因子-I（IGF-I）和雌二醇相互作用以调节神经功能。在本综述中，我们重点关注这种相互作用所涉及的细胞和分子机制。雌激素受体（ERs）和IGF-I受体的表达在中枢神经系统中受到交叉调节，许多神经元和星形胶质细胞同时表达这两种受体。此外，雌二醇激活IGF-I受体及其细胞内信号传导。这种效应可能涉及经典的ERs，因为最近的研究结果表明，ERα可能通过与IGF-I信号传导的某些成分直接相互作用来影响IGF-I在大脑中的作用。反过来，IGF-I可能调节神经元细胞中ER的转录活性。总之，ERs似乎是IGF-I信号传导机制的一部分，而IGF-I受体是神经系统中雌二醇信号传导机制的一部分。
