Caldwell Heather K, Stewart John, Wiedholz Lisa M, Millstein Rachel A, Iacangelo Anna, Holmes Andrew, Young W Scott, Wersinger Scott R
Section on Neural Gene Expression, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA.
Neuropeptides. 2006 Oct;40(5):325-37. doi: 10.1016/j.npep.2006.08.001.
Studies of the role of vasopressin (Avp) in mediating the effects of ethanol have focused on Avp's role in altering kidney function via its action through the vasopressin 2 receptor. However, alcohol consumption also has central effects that are poorly understood. There is evidence that Avp may mediate ethanol consumption as well as some of ethanol's behavioral effects. Centrally only two Avp receptor subtypes are expressed: the 1a receptor (Avpr1a) and the 1b receptor (Avpr1b). To determine the extent to which these receptors mediate the behavioral effects of alcohol, we used mice with targeted disruptions of either their Avpr1a or Avpr1b gene. We examined the effects of genotype on the acute intoxicating effects of ethanol as well as on voluntary ethanol consumption. Surprisingly, our findings indicate that there is no interaction between either the Avpr1a or Avpr1b and ethanol on motor coordination, hypothermia, mood, or voluntary ethanol consumption.
关于血管加压素（Avp）在介导乙醇作用方面的研究主要集中在Avp通过血管加压素2受体发挥作用来改变肾功能。然而，饮酒对中枢的影响却知之甚少。有证据表明，Avp可能介导乙醇摄入以及乙醇的一些行为效应。在中枢仅表达两种Avp受体亚型：1a受体（Avpr1a）和1b受体（Avpr1b）。为了确定这些受体在多大程度上介导酒精的行为效应，我们使用了Avpr1a或Avpr1b基因靶向破坏的小鼠。我们研究了基因型对乙醇急性中毒效应以及自愿乙醇摄入的影响。令人惊讶的是，我们的研究结果表明，Avpr1a或Avpr1b与乙醇在运动协调、体温过低、情绪或自愿乙醇摄入方面均无相互作用。
