Amici Mara De, Moratti Remigio, Quaglini Silvana, Alesina Roberta, Peona Vittoria
Department of Pediatrics, University of Pavia, IRCCS Policlinico S Matteo, Pavia, Italy.
J Asthma. 2006 Oct;43(8):593-6. doi: 10.1080/02770900600878495.
Recruitment and activation of both neutrophils and eosinophils seem to be a characteristic of chronic bronchitis. The purpose of this study was to evaluate whether eosinophil cationic protein and/or myeloperoxidase (ECP/MPO) serum levels differ between patients with chronic obstructive and nonobstructive bronchitis during an exacerbation-free period and if they represent clinical gravity indicators of disease. To identify a correlation between ECP/MPO values in serum and bronco-obstruction, a statistical analysis by logistic regression was used. Study results show that there is a relationship between increased serum levels of ECP and log MPO and an increased risk for forced expiratory volume in 1 second (FEV1) pathologic values associated with obstructive chronic bronchitis, with an ECP odds ratio = 1.04 and logMPO = 4.45.
中性粒细胞和嗜酸性粒细胞的募集与激活似乎是慢性支气管炎的一个特征。本研究的目的是评估在无加重期，慢性阻塞性支气管炎患者与非阻塞性支气管炎患者之间，嗜酸性粒细胞阳离子蛋白和/或髓过氧化物酶（ECP/MPO）的血清水平是否存在差异，以及它们是否代表疾病的临床严重程度指标。为了确定血清中ECP/MPO值与支气管阻塞之间的相关性，采用了逻辑回归进行统计分析。研究结果表明，ECP和log MPO血清水平升高与阻塞性慢性支气管炎相关的1秒用力呼气量（FEV1）病理值风险增加之间存在关联，ECP优势比=1.04，logMPO=4.45。
