Ekstrøm Morten, Lykke Mortensen Erik, Sørensen Holger J, Mednick Sarnoff A
Danish Epidemiology Science Center, Institute of Preventive Medicine, Copenhagen University Hospital, Denmark.
Nord J Psychiatry. 2006;60(5):417-22. doi: 10.1080/08039480600940029.
Schizophrenia has been linked with premorbid character anomalies since it was first described. However, few prospective studies of premorbid personality characteristics in schizophrenia and related disorders have been conducted. This study evaluates premorbid personality in children who developed schizophrenia spectrum disorder in adult life. In 1972, 265 children at an average age of 12 (90 with at least one schizophrenic parent) from the Copenhagen Perinatal Cohort participated in a 1-day follow-up during which they were in contact with seven examiners who rated their personality by means of an Adjective Check List (ACL). In 1991-93, adult psychiatric status was assessed for 242 of these individuals, who were classified into three categories: schizophrenia spectrum (n=24), other psychiatric diagnoses (n=72) and healthy controls (n=145). Personality characteristics derived from the ACL were linked to these three diagnostic categories. Twelve-year-old children destined to develop a disorder in the schizophrenia spectrum deviated significantly from healthy controls on a number of personality characteristics: they were rated significantly lower than controls on intelligence, concentration, maturity, friendliness, cooperation, self-control and significantly higher on aggression. Non-significant trends indicated that this group displayed more deviant personality scores than psychiatric controls. Children who later develop schizophrenia spectrum disorder differed from normal controls with respect to a number of personality traits. The ACL may be too insensitive to discriminate between premorbid personality in the schizophrenia spectrum and other psychopathology.
自精神分裂症首次被描述以来，它就与病前性格异常有关。然而，很少有关于精神分裂症及相关障碍病前人格特征的前瞻性研究。本研究评估了成年后患精神分裂症谱系障碍的儿童的病前人格。1972年，来自哥本哈根围产期队列的265名平均年龄为12岁的儿童（其中90名至少有一位精神分裂症患者父母）参加了为期1天的随访，在此期间，他们与7名考官接触，考官通过形容词检查表（ACL）对他们的人格进行评分。1991年至1993年，对其中242人进行了成人精神状态评估，这些人被分为三类：精神分裂症谱系（n = 24）、其他精神疾病诊断（n = 72）和健康对照（n = 145）。从ACL得出的人格特征与这三个诊断类别相关。注定要患精神分裂症谱系障碍的12岁儿童在一些人格特征上与健康对照有显著差异：他们在智力、注意力、成熟度、友好度、合作性、自我控制方面的评分显著低于对照组，而在攻击性方面的评分显著高于对照组。非显著趋势表明，该组的人格得分比精神疾病对照组更偏离正常。后来患精神分裂症谱系障碍的儿童在一些人格特质上与正常对照组不同。ACL可能对区分精神分裂症谱系的病前人格和其他精神病理学过于不敏感。
