Itoh Yoshifumi
Kennedy Institute of Rheumatology Division, Imperial College London, London, UK.
IUBMB Life. 2006 Oct;58(10):589-96. doi: 10.1080/15216540600962818.
Controlled cell migration is a fundamental and critical event in many physiological processes. However once control is lost, cell migration facilitates disease progression such as seen in cancer metastasis, atherosclerosis, and rheumatoid arthritis. One of the critical proteinases involved in cell migration is membrane-type 1 matrix metalloproteinase (MT1-MMP/MMP-14). MT1-MMP degrades extracellular matrix to make a path for cells to migrate, sheds cell surface molecules to give migratory signals, and activates ERK (extracellular signal-regulated protein kinase) enhancing cell migration. For MT1-MMP to promote cell migration, it needs to act in co-ordination with other cell migration machinery. Understanding such regulatory links may provide insights into the development of novel disease therapies.
受控细胞迁移是许多生理过程中的一个基本且关键的事件。然而，一旦失去控制，细胞迁移就会促进疾病进展，如在癌症转移、动脉粥样硬化和类风湿性关节炎中所见。参与细胞迁移的关键蛋白酶之一是膜型1基质金属蛋白酶（MT1-MMP/MMP-14）。MT1-MMP降解细胞外基质为细胞迁移开辟道路，脱落细胞表面分子以发出迁移信号，并激活细胞外信号调节蛋白激酶（ERK）以增强细胞迁移。为了使MT1-MMP促进细胞迁移，它需要与其他细胞迁移机制协同作用。了解这种调节联系可能为新型疾病疗法的开发提供思路。
