铜绿假单胞菌外毒素U基因的存在与MDCK细胞的细胞毒性相关，但与BALB/c小鼠的定植无关。
Presence of the exoU gene of Pseudomonas aeruginosa is correlated with cytotoxicity in MDCK cells but not with colonization in BALB/c mice.
作者信息
Lin Hsi-Hsun, Huang Shiao-ping, Teng Hsiu-Chen, Ji Dar-Der, Chen Yao-Shen, Chen Ya-Lei
机构信息
Department of Infectious Disease, E-DA Hospital/I-Shou University, Kaoshiung, Taiwan.
出版信息
J Clin Microbiol. 2006 Dec;44(12):4596-7. doi: 10.1128/JCM.01531-06. Epub 2006 Oct 18.
Abstract
A total of 141 independent strains of Pseudomonas aeruginosa with different heterogeneities in the exo gene (exoS, exoT, exoU, and exoY) background were examined for their pathogenic roles. Results indicated that the exoU gene is the major contributor to cytotoxicity in Madin-Darby canine kidney cells but is not related to bacterial colonization in mice.
摘要
共检测了141株在外毒素基因（exoS、exoT、exoU和exoY）背景下具有不同异质性的铜绿假单胞菌独立菌株的致病作用。结果表明，exoU基因是导致Madin-Darby犬肾细胞产生细胞毒性的主要因素，但与小鼠体内的细菌定植无关。
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