Mengreli C, Sarafidou E, Petmezaki S, Pantelakis S
Biochemical Laboratories, Institute of Child Health, Athens, Greece.
Biol Neonate. 1990;58(6):326-33. doi: 10.1159/000243287.
alpha-Fetoprotein (alpha-FP) was measured in dried blood spots from normal, congenital hypothyroid (CH) and transient hyperthyrotropinemic (TH) newborns as well as in serum from CH and TH babies together with thyroxine, triiodothyronine and thyrotropin. The half-life of alpha-FP had a median value of 12 days in the CH cases and 4.9 days in the TH cases. alpha-FP was significantly higher in the CH group before treatment and showed a significant rise after discontinuation of thyroxine therapy. It would appear that thyroid hormones influence alpha-FP metabolism and that a hypothyroid environment results in increased alpha-FP levels.
在正常新生儿、先天性甲状腺功能减退（CH）新生儿和短暂性促甲状腺素血症（TH）新生儿的干血斑中检测了甲胎蛋白（alpha-FP），同时在CH和TH患儿的血清中检测了甲状腺素、三碘甲状腺原氨酸和促甲状腺素。在CH病例中，alpha-FP的半衰期中位数为12天，在TH病例中为4.9天。CH组治疗前alpha-FP显著升高，停用甲状腺素治疗后显著上升。甲状腺激素似乎影响alpha-FP代谢，甲状腺功能减退环境会导致alpha-FP水平升高。
