Goodman B, Zheng Y
Department of Embryology, Carnegie Institution of Washington, Johns Hopkins University, Baltimore, MD 21218, USA.
Biochem Soc Trans. 2006 Nov;34(Pt 5):716-21. doi: 10.1042/BST0340716.
Assembly and disassembly of the mitotic spindle are essential for both chromosome segregation and cell division. The small G-protein Ran has emerged as an important regulator of spindle assembly. In this review, we look at the role of Ran in different aspects of spindle assembly, including its effects on microtubule assembly dynamics and microtubule organization. In addition, we examine the possibility of a spindle matrix and the role Ran might play in such a structure.
有丝分裂纺锤体的组装和解聚对于染色体分离和细胞分裂都至关重要。小G蛋白Ran已成为纺锤体组装的重要调节因子。在这篇综述中，我们探讨Ran在纺锤体组装不同方面的作用，包括其对微管组装动力学和微管组织的影响。此外，我们研究了纺锤体基质的可能性以及Ran在这种结构中可能发挥的作用。
