Wenger Nanette K
Department of Medicine (Cardiology), Emory University School of Medicine, the Department of Cardiology, Grady Memorial Hospital, and the Emory Heart & Vascular Center, Atlanta, Georgia 30303, USA.
Cardiol Rev. 2006 Nov-Dec;14(6):276-80. doi: 10.1097/01.crd.0000240528.66999.ed.
In multiple randomized, controlled clinical trials, statin treatment of elevated low-density lipoprotein cholesterol in women at increased risk of or with coronary heart disease decreased the risk of coronary events: coronary death, nonfatal myocardial infarction, and myocardial revascularization procedures. Total mortality was unchanged, potentially reflecting the underrepresentation of women in these trials and consequent small number of fatal events. Statin therapy provided comparable benefit for women and men with acute coronary syndromes. Application of lipid-lowering therapy with statin drugs is currently underutilized in women, and represents an opportunity to improve clinical cardiovascular outcomes for women.
在多项随机对照临床试验中，他汀类药物用于治疗冠心病风险增加或已患冠心病的女性患者的低密度脂蛋白胆固醇升高，可降低冠心病事件风险：冠心病死亡、非致死性心肌梗死以及心肌血运重建术。总死亡率未变，这可能反映出这些试验中女性代表性不足，因此致命事件数量较少。他汀类药物治疗为患有急性冠脉综合征的女性和男性带来的益处相当。目前，他汀类降脂药物在女性中的应用未得到充分利用，这是改善女性临床心血管结局的一个契机。
