Gehlen H, Weichler A, Bubeck K, Ohnesorge B, Deegen E, Stadler P
Klinik für Pferde, Tierärztliche Hochschule Hannover, Bischofsholer Damm 15, D-30173 HannoverKlinik für Pferde, Tierärztliche Hochschule Hannover, Bischofsholer Damm 15, D-30173 Hannover, Germany.
J Vet Med A Physiol Pathol Clin Med. 2006 Nov;53(9):476-80. doi: 10.1111/j.1439-0442.2006.00860.x.
The purpose of the present study was to investigate the effects of two different dobutamine concentrations on pulmonary artery wedge pressure (PAWP) and on mean systemic arterial blood pressure (MAP) in horses anaesthetized with isoflurane, after induction of general anaesthesia with xylazine, ketamine and diazepam. Eight healthy warm-blood horses were included in the study. Each horse was subjected to general anaesthesia twice with two different dosages of dobutamine, 3 and 5 microg/kg bw/min, being infused over 15 min, starting 50 min after induction of general anaesthesia (T(0)). The heart rate, the PAWP and the MAP were recorded after 10 min (T(1)) and then every 5 min until 15 min after cessation of intravenous dobutamine administration (T(3)-T(5)). The PAWP was measured by a right heart catheter, which was positioned in the pulmonary capillaries. Mean systemic arterial blood pressure was monitored at the facial artery for the duration of general anaesthesia. All parameters increased at both dosage rates of dobutamine and decreased significantly when dobutamine administration ceased. The increase in heart rate was significantly higher after administration of 3 microg/kg bw/min dobutamine compared with the dosage of 5 microg/kg bw/min dobutamine. The increase in MAP was also higher at this dosage, but not significantly different to the dosage of 5 microg/kg bw/min dobutamine. During both dosages the MAP was above a value considered to be compatible with good peripheral circulation. The greater increase in PAWP was observed during administration of 5 g/kg bw/min dobutamine, but PAWP was not significantly different with the dosage of 3 microg/kg bw/min dobutamine. In conclusion, the administration of dobutamine led to an increase in MAP and PAWP above a value considered to be compatible with a good peripheral circulation. The results of the present study indicate that dobutamine improves circulation, in addition to its well-known effect on the periphery.
本研究的目的是探讨在以赛拉嗪、氯胺酮和地西泮诱导全身麻醉后，用异氟烷麻醉的马匹中，两种不同浓度的多巴酚丁胺对肺动脉楔压（PAWP）和平均体循环动脉血压（MAP）的影响。八匹健康的温血马被纳入研究。每匹马用两种不同剂量的多巴酚丁胺进行两次全身麻醉，剂量分别为3和5微克/千克体重/分钟，在全身麻醉诱导后50分钟（T(0)）开始，持续输注15分钟。在10分钟后（T(1)）记录心率、PAWP和MAP，然后每5分钟记录一次，直至静脉注射多巴酚丁胺停止后15分钟（T(3)-T(5)）。PAWP通过置于肺毛细血管中的右心导管测量。在全身麻醉期间，在面动脉监测平均体循环动脉血压。两种多巴酚丁胺剂量率下所有参数均升高，多巴酚丁胺给药停止后显著下降。与5微克/千克体重/分钟的多巴酚丁胺剂量相比，给予3微克/千克体重/分钟的多巴酚丁胺后心率增加显著更高。在此剂量下MAP的增加也更高，但与5微克/千克体重/分钟的多巴酚丁胺剂量无显著差异。在两种剂量期间，MAP均高于被认为与良好外周循环相符的值。在给予5微克/千克体重/分钟的多巴酚丁胺期间观察到PAWP的更大增加，但与3微克/千克体重/分钟的多巴酚丁胺剂量相比，PAWP无显著差异。总之，多巴酚丁胺的给药导致MAP和PAWP升高至高于被认为与良好外周循环相符的值。本研究结果表明，多巴酚丁胺除了对周围有众所周知的作用外，还能改善循环。
