精神分裂症1型基因与精神分裂症的阳性症状紊乱
Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia.
作者信息
DeRosse Pamela, Hodgkinson Colin A, Lencz Todd, Burdick Katherine E, Kane John M, Goldman David, Malhotra Anil K
机构信息
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York 11004, USA.
出版信息
Biol Psychiatry. 2007 May 15;61(10):1208-10. doi: 10.1016/j.biopsych.2006.07.023. Epub 2006 Oct 19.
BACKGROUND
Converging evidence has demonstrated an association between the Disrupted in Schizophrenia 1 (DISC1) gene and schizophrenia (SZ). Within the DISC1 gene, a single nucleotide polymorphism (SNP), Ser704Cys, has been associated with the structure and function of the hippocampus. Because positive symptoms in SZ have also been associated with hippocampal structure and function, we hypothesized that variation in a DISC1 haplotype containing Ser704Cys would be significantly associated with positive symptomatology in SZ.
METHODS
We tested for an association between variation in a haplotype block within the DISC1 gene containing Ser704Cys and lifetime history of positive symptoms in 199 Caucasian patients with SZ.
RESULTS
We detected significant associations between a DISC1 haplotype containing Ser704Cys and Ser704Cys genotype and lifetime severity of delusions in SZ.
CONCLUSIONS
These data suggest that that the effect of DISC1 genetic variation might be associated with positive symptoms in patients with SZ.
背景
越来越多的证据表明，精神分裂症1（DISC1）基因与精神分裂症（SZ）之间存在关联。在DISC1基因中，单核苷酸多态性（SNP）Ser704Cys与海马体的结构和功能有关。由于SZ的阳性症状也与海马体结构和功能有关，我们假设包含Ser704Cys的DISC1单倍型变异与SZ的阳性症状学显著相关。
方法
我们测试了199名患有SZ的白种人患者中，包含Ser704Cys的DISC1基因单倍型块变异与阳性症状的终生史之间的关联。
结果
我们检测到包含Ser704Cys的DISC1单倍型、Ser704Cys基因型与SZ患者终生妄想严重程度之间存在显著关联。
结论
这些数据表明，DISC1基因变异的影响可能与SZ患者的阳性症状有关。
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