一种强效、特异性的基于氮杂双环[3.3.0]辛烷的二肽基肽酶II抑制剂的合成与活性
Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor.
作者信息
Danilova Olga, Li Bei, Szardenings A Katrin, Huber Brigitte T, Rosenblum Jonathan S
机构信息
Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA.
出版信息
Bioorg Med Chem Lett. 2007 Jan 15;17(2):507-10. doi: 10.1016/j.bmcl.2006.10.012. Epub 2006 Oct 10.
Abstract
A cell permeable DPP II [also known as DPP2, DPP7, and quiescent cell proline dipeptidase (QPP)] inhibitor has been synthesized. The azabicyclo[3.3.0]octane-based inhibitor is potent and selective and elicits very similar quiescent lymphocyte death to previously characterized inhibitors that are not as selective.
摘要
一种细胞可渗透的二肽基肽酶II（也称为DPP2、DPP7和静止细胞脯氨酸二肽酶（QPP））抑制剂已被合成。这种基于氮杂双环[3.3.0]辛烷的抑制剂具有高效性和选择性，并且能引发与之前特征化的、选择性不如它的抑制剂非常相似的静止淋巴细胞死亡。
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